Chromosome substitution strains

WebJun 29, 2016 · Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain. However, statistical significance as … WebDec 16, 2008 · Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and …

(PDF) Chromosome Substitution Strains - ResearchGate

WebJun 12, 2006 · An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting … WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain … some fun tonight facebook https://cashmanrealestate.com

(PDF) Chromosome Substitution Strains - ResearchGate

WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We … WebJul 8, 2003 · A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substi-tuted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for … WebChromosome substitution strains (CSS) were originally obtained as a gift from Dr. Joseph Nadeau (Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106). Each CSS is a homozygous inbred strain that is C57BL/6J with one chromosome pair from A/J. small business on wheels

Chromosome Substitution Strain - an overview

Category:Genetic Dissection of Complex Traits with Chromosome Substitution ...

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Chromosome substitution strains

(PDF) Chromosome Substitution Strains

WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to … WebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way ( 20 ). Each CSSs is an inbred strain that differs from the host strain by a single intact and homozygous chromosome on a defined and uniform genetic background.

Chromosome substitution strains

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WebRecombinant inbred (RI) and chromosome substitution (CS) strain panels Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, … WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,...

WebMar 28, 2024 · 5.3 Chromosome Substitution or Consomic Strains 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains 5.5 Conplastic Strains 6. Outbreds and Closed Colonies 6.1 Outbreds 6.2 Closed Colonies 7. ES cell lines and iPS cell lines 8. References 1. Introduction Mice and rats used in the laboratory derive from a variety of sources. WebGenetic resistance to diet-induced obesity in chromosome substitution strains of mice.pdf. 2011-11-03 ...

WebJAX® Mice substrains were used to generate panels of consomic (chromosome substitution) strains for use as gene mapping tools 21. The Complex Trait Consortium (www.complextrait.org) plans to use JAX® Mice substrains as progenitor strains for the generation of >500 recombinant inbred strains 22.

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WebChromosome Substitution Strain Consomic. A consomic strain of animals is an inbred strain in which a whole chromosome – rather than one local... Genetic Monitoring of Laboratory Mice and Rats. Marjorie C. Strobel PhD, ... ... Congenic (and consomic) … some game crosswordWebDec 1, 2003 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations ... some fun tonight beatlesWebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy506 strains. small business on time payment policyWebChromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … some game pieces crossword clueWebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... small business ontario registrationWebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, … some game show prizes crosswordWebChromosome substitution strains (CSSs) are a powerful complement to existing resources for studying multigenic traits. By partitioning the genome into a panel of … small business open sign