Cisplatin mitochondria

WebJul 14, 2024 · Here we have extended this strategy by coordinating in the axial positions of kiteplatin ( [PtCl₂ ( cis -1,4-DACH)], DACH = Diaminocyclohexane) and its CBDCA (1,1-cyclobutanedicarboxylate) analogue the antioxidant α-Lipoic acid (ALA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK). WebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis.

Cisplatin nephrotoxicity: new insights and therapeutic implications ...

WebJul 1, 2024 · Background: Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. WebCisplatin is a platinum-based chemotherapeutic agent that induces peripheral neuropathy in 30% of patients. Peripheral neuropathy is the dose limiting side effect, which has no preventative therapy. We have previously shown that cisplatin induces apoptosis in dorsal root ganglion (DRG) sensory neuro … dynamic technical gadget https://cashmanrealestate.com

Metformin potentiates the anticancer effects of cisplatin under ...

WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as … WebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. In this work, theranostic Pt(IV)-NPs, which are precisely self-assembled b … WebJul 6, 2016 · Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined. cs 137 branching ratio

The cardioprotective effect of human glucagon-like peptide-1 …

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Cisplatin mitochondria

Cancer Drug 49 Times More Potent than Cisplatin

WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as ovarian, colorectal, prostate, lung, and... WebApr 23, 2024 · Cisplatin / toxicity Drugs, Chinese Herbal / therapeutic use* Humans Hyperalgesia / chemically induced Hyperalgesia / drug therapy Membrane Potential, Mitochondrial / drug effects Mice Neurotoxicity Syndromes Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Drugs, Chinese Herbal

Cisplatin mitochondria

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WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell... WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news

WebJul 10, 2024 · Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic … WebApr 11, 2024 · Introduction. Ovarian cancer (OC) is a lethal gynecological malignancy. Most OC patients benefit from initial treatments with cytoreductive surgery followed by cisplatin (CP)-based chemotherapy 1.However, approximately 70% of OC patients relapse and develop drug-resistance after long-term use of CP 2.Multilayer alterations have been …

WebNov 19, 2013 · Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is … WebNational Center for Biotechnology Information

WebThe cellular uptake of cisplatin and its targets. Reprinted with permission. 1 As seen in Figure 1, once inside the cell, cisplatin has a number of possible targets: DNA; RNA; sulfur-containing enzymes such as metallothionein and glutathione; and mitochondria.

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), which is used primarily for the treatment of DM. dynamic technology lab testWebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … dynamic technology incWebMar 20, 2024 · Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro. Astrocytes are key players in supporting … dynamic tattoo ink setWebmaintaining mitochondrial number and function is dem-onstrated by studies showing that the maturation of oo-cytes is severely impaired when mitochondrial activities are sub-optimal [26, 27]. Cisplatin is known to damage the DNA of oocytes, but the possibility that cisplatin also compromises oocyte survival and quality by damaging mitochondria ... cs-137 energy spectrumWebNational Center for Biotechnology Information cs-137 gamma spectrumWebJul 7, 2014 · A mitochondria-targeted Pt(IV)-prodrug of cisplatin, Platin-M, was designed by introducing two mitochondria-targeting delocalized lipophilic TPP cations in the axial positions (Fig. 1A). Recently, a Pt(II) … cs-137 half-lifedynamic technology lab怎么样