WebO both ATP and CTP affect the Vmax of ATCase ATP decreases Ko.s, while CTP increases ko. O ATP affects K0.5, while CTP affects Vmax O neither ATP nor CTP are ATCase … Web考博 生物化学与分子 20241 182012 生化分子一 名词解释1. 氧化磷酸化答案伴随电子从底物到氧的传递,ADP 被磷酸化形成 ATP 的酶促过程即是氧化磷酸化作用oxidative phosphorylation.氧化磷酸化的全过
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WebQ1: What is the effect of CTP on the activity of ATCase? A) It stabilizes the T-state of ATCase and increases the activity of the enzyme B) It stabilizes the T-state of ATCase and decreases the activity of the neyzme C) It stabilizes the R-state of ATCase and increases the activity of the enzyme With CTP present, UTP binding is enhanced and preferentially directed to the low-affinity sites. On the converse, UTP binding leads to enhanced affinity for CTP at the high-affinity sites and together they inhibit enzyme activity by up to 95%, while CTP binding alone inhibits activity to 50% to 70%. [3] See more Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (EC 2.1.3.2). In See more The discussion of structure, catalytic center, and allosteric site that follows is based on the prokaryotic version of ATCase, specifically See more The allosteric site in the allosteric domain of the R chains of the ATCase complex binds to the nucleotides ATP, CTP and/or UTP. There is one site with high affinity for ATP and CTP and one with 10- to 20-fold lower affinity for these nucleotides in each regulatory dimer. … See more • Aspartate+carbamoyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more ATCase is a highly regulated enzyme that catalyses the first committed step in pyrimidine biosynthesis, the condensation of See more The catalytic site of ATCase is located at the interface between two neighboring catalytic chains in the same trimer and incorporates amino … See more The regulatory and catalytic subunits exist as fused protein homologs, providing strong evidence that they would interact together. Two … See more raw 2007 download for pc
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WebNov 16, 2016 · Cytidine triphosphate (CTP), which is an end product of the pyrimidine biosynthetic pathway, has a negative allosteric effect on ATCase activity, while adenosine triphosphate, ATP, has a positive … WebThe inhibitor CTP binds preferentially to the ___ state of ATCase t The metabolic significance of the activation of ATCase by __________ is that it tends to coordinate the rates of synthesis of purines and pyrimidines. ATP The effects of uncompetitive inhibition on Vmax are not reversed by increasing substrate concentration. True WebNov 12, 2013 · Abstract. For nearly 60 years, the ATP activation and the CTP inhibition of Escherichia coli aspartate transcarbamoylase (ATCase) has been the textbook example of allosteric regulation. We present kinetic data and five X-ray structures determined in the absence and presence of a Mg (2+) concentration within the physiological range. raw 2007 theme