WebTemporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat Cancer 2024; 3 (1):108–121. 7. Bassez A, et al . A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. Nat Med 2024; 27 (5):820–832. Web23 Dec 2024 · Our data suggested that Texp cells were unlikely to be derived from the reinvigoration of terminally exhausted cells; instead, they were accumulated by (1) local expansion and (2) replenishment... Full Size Image - Temporal single-cell tracing reveals clonal revival and ... - Nature

Temporal single-cell tracing reveals clonal revival and expansion …

Web20 Jan 2024 · Temporal dynamics of T cells following PD-1 blockade Single-cell sequencing reveals temporal changes in tumor-infiltrating T cell populations before and … WebAnti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood. Here, we performed temporal single-cell RNA and paired T-cell receptor sequencing on 47 tumor biopsies from 36 patients with NSCLC following PD-1-based … map of cape horn and antarctica

Stem cell growth becomes predominant while neural plate …

WebThe relative importance of both of these cell behaviors during the long period of elongation is poorly understood. Here, we use a combination of single cell lineage tracing in the mouse embryo, computer modeling and confocal video-microscopy of GFP labeled cells in the chick embryo to address the mechanisms involved in the antero-posterior dispersion of clones. Web2 Jan 2024 · Using single-cell RNA and TCR sequencing, we traced the clonal expansion and differentiation of CD8+ T cells during chronic LCMV infection. We identified immense … Web13 Sep 2011 · Clonal analyses, which describe the derivatives of a single cell, provide insight into the mode of growth of a tissue and its regionalization with potential clonal boundaries (Garcia-Bellido et al., 1973) between compartments, or with segregation between distinct cell lineages, which do not necessarily correspond to distinct differentiated cell types but … map of cape cod and the islands